| No | Hotel | Rooms | Score | |
|---|---|---|---|---|
| 1 |  |
Embassy Suites by Hilton Saint Louis Saint Charles | 309 | 8.50 |
| 2 | |
Best Western Plus The Charles Hotel | 132 | 7.50 |
| 3 | |
Hampton Inn St Charles St Peters | 122 | 7.70 |
| 4 | |
Relax Inn Saint Charles | 92 | 6.20 |
| 5 | |
Country Inn & Suites by Radisson, St Charles Historic District | 65 | 9.10 |
| 6 | |
Americas Best Value Inn and Suites Saint Charles | 64 | 4.30 |
| 7 | |
Holiday Inn Express Hotel & Suites St. Charles by IHG | 60 | 8.30 |
| 8 | |
Super 8 by Wyndham St Charles | 52 | 7.80 |
| 9 | |
Sleep Inn | 49 | 4.20 |