| No | Hotel | Rooms | Score | |
|---|---|---|---|---|
| 1 |  |
Sleep Inn & Suites Hannibal | 67 | 9.10 |
| 2 | |
Days Inn by Wyndham Hannibal | 61 | 5.90 |
| 3 | |
Quality Inn & Suites | 56 | 7.70 |
| 4 | |
Super 8 by Wyndham Hannibal | 56 | 6.70 |
| 5 | |
Best Western On the River | 9 | 8.10 |