| No | Hotel | Rooms | Score | |
|---|---|---|---|---|
| 1 |  |
Drury Plaza Hotel Cape Girardeau Conference Center | 238 | 9.40 |
| 2 | |
Auburn Place Hotel & Suites | 103 | 8.30 |
| 3 | |
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG | 102 | 8.50 |
| 4 | |
Drury Inn & Suites Cape Girardeau | 85 | 9.10 |
| 5 | |
Hampton Inn Cape Girardeau I-55 East, MO | 83 | 9.30 |
| 6 | |
Pear Tree Inn Cape Girardeau West | 79 | 8.60 |
| 7 | |
Pear Tree Inn Cape Girardeau Medical Center | 78 | 8.60 |